This 100 year old drummer perhaps makes a case that it's never too late to start playing an instrument.  There are workarounds for many different physical circumstances, and certain instruments are better suited for people with hand, arm, and back pain.  Guitar and drums are popular, but there are also less common ones like the theremin, harmonica, mouth harp, and keyboards without weighted keys.

Need some more motivation?  How about a really hot drummer who can play insanely well?  Same goes for Jeff Beck's bassist, Tal Wilkenfeld.

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